nitroimidazoles viii [i]. syntheses, antibacterial and antifungal activities of 2-pyridyl-nitroimidazoles
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abstract
starting from 2-(2-pyridyl) imidazole a series of substituted imidazoles (2-5) were prepared. from the reaction of 2-(3-pyridyl) -4-(or 5) nitroimidazole (15) with dimethyl sulfate in alkaline medium 1-methyl-2-(3- pyridy1)-4-nitroimidazole (6,)w as prepared. reaction of compound 15 with diazomethane gave i-methyl-2-(3-pyridy1)-5- nitroimidazol(e7 ) in addition to 6. the antibacterial and antifungal activities of compounds 5, 6, and 7 against a number of microorganisms were determined
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Journal title:
journal of sciences islamic republic of iranجلد ۱، شماره ۳، صفحات ۰-۰
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